Endocrine Abstracts

Introduction: Turner Syndrome (TS) is associated with cardiovascular anomalies and account for a threefold higher mortality in these women. The most common findings are congenital malformations of the heart (CMH), aortic dissection, valvular heart disease (VHD), hypertension and ischemic heart disease. It has been suggested that the ocurrence of cardiovascular disease in TS women is related to their karyotype and possibly to growth hormone (GH) treatment. Our study aimed to as...

Introduction: Adult-onset autoimmune diabetes (AID) has two different phenotypes: classic type 1 diabetes mellitus (T1DM), with insulin requirement just after diagnosis, and latent autoimmune diabetes in adults (LADA). According to the Immunology of Diabetes Society, LADA diagnostic criteria are: age of onset of 30 years or more, any islet autoantibody, absence of insulin requirement for at least 6 months. The purpose of this study is to characterize patients with AID followed...

Introduction: Primary aldosteronism (PA) is the principal cause of arterial hypertension potentially treatable. The diagnosis is dependent of tests to identify patients who will benefit most with surgical treatment. ACTH stimulation test (AST) has been described as a useful confirmatory test, potentially identifying bilateral disease in patients without adrenal tumors.Aim: Evaluate the AST in patients with hypertension and positive screening test for PA,...

Introduction: Pheochromocytomas are catecholamine-producing tumors originated from the chromaffin cells of the adrenal medulla. Although usually sporadic, this tumors could be associated with germline mutations in about 40% of cases. TMEM127 has recently been identified as a novel gene conferring increased susceptibility to pheochromocytoma.Case report: A 42-year-old woman was referred to our Hospital to perform a right adrenalectomy for pheochromocytoma...

Introduction: Performance-enhancing drug (PED) use is currently a common practice both inside and outside the sports competition scenario, and its adverse health effects remain underappreciated.Case report: We report the case of a 26-year-old man, bodybuilding practitioner, no relevant medical history, family history of autoimmune disorders. Referred to the emergency room with polydipsia, polyuria, blurred vision associated with a post-prandial capillary...

Introduction: Dapagliflozin is an oral antidiabetic drug, recently approved for type 2 diabetes and is a sodium-glucose cotransporter type 2 inhibitor (iSGLT2). Its mechanism of action is glycosuria induction, associated with lowering glycemia. The effects of SGLT2 inhibition are insulin-independent, and efficacy is not affected by declining β-cell function or insulin resistance. Additional benefits: weight loss, reduction in blood pressure, lower inciden...

Introduction: The American Diabetes Association proposed two categories for the classification of type 1 diabetes mellitus (DM): autoimmune (AI) and idiopathic (ID). The absence of autoimmune markers or association with HLA haplotypes defines the second category. Only a small minority of patients with type 1 diabetes fall into this category.Objective: To evaluate the clinical characteristics of both categories and to analyze the differe...

Background: The diagnosis of Cushing’s syndrome (CS) remains a challenge in clinical endocrinology. Several screening tests have been proposed to establish hypercortisolism. Late-night salivary cortisol (LNSC) is used as screening tool, however, individualized cut-off levels for each population must be defined.Methods: Three group of subjects were studied: healthy volunteers, suspected CS and proven CS. All patients collected saliva at 23.00 h using...

Introduction: MEN1 is a rare autosomal dominant syndrome typically characterized by neoplastic lesions of parathyroid glands, anterior pituitary gland and endocrine pancreas. Several other tumours are associated with this syndrome, including adrenal lesions, but their prevalence and clinical characteristics (endocrine secretion and aggressiveness) are largely unknown.Objective: To determine the prevalence, clinical characteristics and the possible genoty...

Introduction: Glycogen storage disease (GSD) type Ia (von Gierke’s disease) is an inherited metabolic disorder of glycogen metabolism, caused by defects in the glucose-6-phosphatase complex, with associated risk of severe hypoglycemia within 3–4 h after a meal.The aim of the present study was to evaluate the efficacy of continuous glucose monitoring (CGM) system in determining the magnitude of hypoglycemia in patients with GSD type Ia.<p cl...